Canceris a broad group of diseases involving unregulated cell growth. In cancer, cells divide and grow uncontrollably, forming malignant tumors, and invading nearby parts of the body. The cancer may also spread to more distant parts of the body through the lymphatic system or bloodstream. Not all tumors are cancerous; benign tumors do not invade neighboring tissues and do not spread throughout the body. There are over 200 different known cancers that affect humans.Read More....

Mounting evidence indicates that microglial activation contributes to tumor growth and metastasis in many types of cancers including brain, breast, colorectal, prostate and lung cancers. One way that the microglia contributes to tumor growth is by the excessive production of hyaluronidase, an enzyme known to promote tumor growth.

A glioma is a primary brain tumor that originates from the supportive cells of the brain, called glial cells. Glioma and often are malignant by the time they are diagnosed.Brain tumors need microglial cells to be activated for them to grow

Medical Research
Microglia Promotes Glioma ProgressionRead More....
“Activation of the microglial cells increased glioma size through stimulating tumor proliferation and
inhibiting apoptosis”

Breast cancer patients typically develop brain metastases years after their initial diagnosis.

Medical Research
Microglia promote colonization of brain tissue by breast cancer cellsRead More....
“Microglia are critical for the successful colonization of the brain by epithelial cancer cells, suggesting inhibition of proinvasive microglia as a promising antimetastatic strategy.”

The brain is a common metastatic site for various types of cancers, especially lung cancer. Patients with brain metastases have a poor prognosis in spite of radiotherapy and/or chemotherapy.

Medical Research
Interaction between lung cancer cells and astrocytes via specific inflammatory cytokines in the microenvironment of brain metastasis Read More....
“The interaction between metastatic tumor cells and activated astrocytes are important in creating a favorable microenvironment for the tumor cells in the brain. They stimulate each other; first lung tumor cells stimulate astrocytes by releasing IL-8, MIF, and PAI-1, then activated astrocytes stimulate the proliferation of tumor cells by releasing cytokines such as TNF-α, IL-1β, and IL-6. These mutual relationships may be important to understand how lung cancer cells metastasize and develop in the brain.”

Colorectal cancer, also known as colon cancer, rectal cancer, or bowel cancer, is a cancer from uncontrolled cell growth in the colon or rectum (parts of the large intestine), or in the appendix.

Medical Research
Involvement of hyaluronidases in colorectal cancer Read More....
“A high association of hyaluronidases in colorectal cancer was observed. Each hyaluronidase presented different tissue distribution, which indicated the implication of certain isoforms in certain cancer stages. The results provided new evidence on the mechanisms involved in the progression of colorectal cancer.”

Prostate cancer is a form of cancer that develops in the prostate, a gland in the male reproductive system.

Medical Research
Involvement of hyaluronidases in colorectal cancerRead More....
“A high association of hyaluronidases in colorectal cancer was observed. Each hyaluronidase presented different tissue distribution, which indicated the implication of certain isoforms in certain cancer stages. The results provided new evidence on the mechanisms involved in the progression of colorectal cancer.”